Funding:
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Kobilka Institute of Innovative Drug Discovery
The Chinese University of Hong Kong, Shenzhen
School of Life and Health Sciences (LHS)
H.L. Tu Building, Room RB705-3
Longxiang Road 2001, Longgang district,
Shenzhen, Guangdong, China, 518172
 

Publications

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2019

Chang C, Young LN, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K,

    Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH.

    Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

    (2019) Mol Cell, 73(2):339-353.e6.

Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley JH, Schekman R.

    Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex.

    (2019) Mol Biol Cell., 30(9):1098-1107.

2018

Kempf, G., Stjepanovic, G., Sloan, J., Hendricks, A., Lapouge, K., Sinning, I.

    The Escherichia coli SRP Receptor Forms a Homodimer at the Membrane

    (2018) Structure, pii: S0969-2126(18)30254-5. 

Gardner, B.M., Castanzo, D.T., Chowdhury, S., Stjepanovic, G., Stefely, M.S., Hurley, J.H., Lander, G.C., Martin, A.

    The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

    (2018) Nature Communications, 9 (1), art. no. 135.

Kasinath, V., Faini, M., Poepsel, S., Reif, D., Feng, X.A., Stjepanovic, G., Aebersold, R., Nogales, E.

    Structures of human PRC2 with its cofactors AEBP2 and JARID2

    (2018) Science, 359 (6378), pp. 940-944.

2017

Su, M.-Y., Morris, K.L., Kim, D.J., Fu, Y., Lawrence, R., Stjepanovic, G., Zoncu, R., Hurley, J.H.

    Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

    (2017) Molecular Cell, 68 (5), pp. 835-846.e3.

Stjepanovic, G., Baskaran, S., Lin, M.G., Hurley, J.H.

    Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex

    (2017) Molecular and Cellular Oncology, 4 (6), art. no. e1367873.

Stjepanovic, G., Baskaran, S., Lin, M.G., Hurley, J.H.

    Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex

    (2017) Molecular Cell, 67 (3), pp. 528-534.e3.

Qi, S., Li, Z., Schulze-Gahmen, U., Stjepanovic, G., Zhou, Q., Hurley, J.H.

    Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

    (2017) Nature Communications, 8, art. no. 14076.

2016

Schulze-Gahmen, U., Echeverria, I., Stjepanovic, G., Bai, Y., Schneidman-Duhovny, D., Doudna, J.A., Zhou, Q., Sali, A., Hurley, J.H.

    Insights into HIV-1 proviral transcription from integrative structure and dynamics of the tat:AFF4:P-TEFB:TAR complex

    (2016) eLife, 5, art. no. e15910.

2015

Qi, S., Kim, D.J., Stjepanovic, G., Hurley, J.H.

    Structure of the human Atg13-Atg101 HORMA heterodimer: An interaction hub within the ULK1 complex

    (2015) Structure, 23 (10), pp. 1848-1857.

Yang, B., Stjepanovic, G., Shen, Q., Martin, A., Hurley, J.H.

    Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

    (2015) Nature Structural and Molecular Biology, 22 (6), pp. 492-498.

Davies, C.W., Stjepanovic, G., Hurley, J.H.

    How the Atg1 complex assembles to initiate autophagy

    (2015) Autophagy, 11 (1), pp. 185-186.

2014

Stjepanovic, G., Davies, C.W., Stanley, R.E., Ragusa, M.J., Kim, D.J., Hurley, J.H.

    Assembly and dynamics of the autophagy-initiating Atg1 complex

    (2014) Proceedings of the National Academy of Sciences of the United States of America, 111 (35), pp. 12793-12798.

Baskaran, S., Carlson, L.-A., Stjepanovic, G., Young, L.N., Kim, do J., Grob, P., Stanley, R.E., Nogales, E., Hurley, J.H.

    Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

    (2014) eLife, 3, art. no. e05115.

2012

Kressler, D., Bange, G., Ogawa, Y., Stjepanovic, G., Bradatsch, B., Pratte, D., Amlacher, S., Strauß, D., Yoneda, Y., Katahira, J.,                Sinning, I., Hurt, E.

    Synchronizing nuclear import of ribosomal proteins with ribosome assembly

    (2012) Science, 338 (6107), pp. 666-671.

2011

Stjepanovic, G., Kapp, K., Bange, G., Graf, C., Parlitz, R., Wild, K., Mayer, M.P., Sinning, I.

    Lipids trigger a conformational switch that regulates Signal Recognition Particle (SRP)-mediated protein targeting

    (2011) Journal of Biological Chemistry, 286 (26), pp. 23489-23497.

 

2010

Erez, E., Stjepanovic, G., Zelazny, A.M., Brugger, B., Sinning, I., Bibi, E.

    Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo

    (2010) Journal of Biological Chemistry, 285 (52), pp. 40508-40514.

2009

Bozkurt, G., Stjepanovic, G., Vilardi, F., Amlacher, S., Wild, K., Bange, G., Favaloro, V., Rippe, K., Hurt, E., Dobberstein, B., Sinning, I.

    Structural insights into tail-anchored protein binding and membrane insertion by Get3

    (2009) Proceedings of the National Academy of Sciences of the United States of America, 106 (50), pp. 21131-21136.

 

2008

Ravaud, S., Stjepanovic, G., Wild, K., Sinning, I.

    The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate          binding cleft

    (2008) Journal of Biological Chemistry, 283 (14), pp. 9350-9358.  

2007

Parlitz, R., Eitan, A., Stjepanovic, G., Bahari, L., Bange, G., Bibi, E., Sinning, I.

   Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding

   amphipathic  helix

   (2007) Journal of Biological Chemistry, 282 (44), pp. 32176-32184.

Bahari, L., Parlitz, R., Eitan, A., Stjepanovic, G., Bochkareva, E.S., Sinning, I., Bibi, E.

    Membrane targeting of ribosomes and their release require distinct and separable functions of FtsY

    (2007) Journal of Biological Chemistry, 282 (44), pp. 32168-32175.

Kriško, A., Stjepanović, G., Pifat, G., Ruysschaert, J.-M., Goormaghtigh, E.

    Detection of apolipoprotein B100 early conformational changes during oxidation

    (2007) Biochimica et Biophysica Acta - Biomembranes, 1768 (11), pp. 2923-2930.